Trulance (Plecanatide)

Trulance (Plecanatide) is a prescription medication used to treat people diagnosed with irritable bowel syndrome with Constipation (IBS-C) and chronic Constipation of unknown origin (chronic idiopathic Constipation - CIC). The active ingredient in Trulance is Plecanatide. Plecanatide belongs to the class of medication called Guanylate Cyclase-C Agonists. Trulance works in the upper gastrointestinal tract to stimulate the intestinal fluid secretion and support regular bowel function. It also helps relieve abdominal (stomach) pain. It does this by replicating the activity of uroguanylin, a naturally secreted chemical, during digestion.

Manufacturer Information

Get medical help immediately if you have any of these signs of an allergic reaction while taking Trulance. The most common side effects of Trulance may include:
• Abdominal pain;
• Abdominal distension;
• Diarrhea;
• Flatulence;
• Vomiting

Contact your doctor right away if you have any of the serious side effects, including:
• Hypersensitivity reactions including skin itching, hives, and rash;
• Severe diarrhea;
• Worsening of your condition

You should not take Trulance if you are allergic to Plecanatide or have been diagnosed with intestinal obstruction. Trulance comes as a tablet, and it can be taken with or without food. You should use it according to your doctor’s prescription. You should inform your doctor if you have a problem taking your medication. If you experience severe diarrhea, you should consult your doctor immediately. Before you start taking this medication, tell your doctor about your medical history, especially if you:
• Are breastfeeding or plan to breastfeed;
• Are pregnant or plan to become pregnant;
• Are younger than 6 years of age;
• Have intestinal obstruction

Tell your doctor immediately if you become pregnant or think you may be pregnant. It is not known if Trulance will harm your unborn baby. You should discuss this with your doctor before using Trulance during pregnancy. It is not known if Trulance passes into your breast milk. Talk with your doctor about the best way to feed your baby if you take Trulance. You should not give Trulance to children who are less than 6 years of age. It may harm them. Tell your doctor about all your medications, including prescription, OTC, herbal supplements, and vitamins. There may be a drug interaction between Plecanatide and other medications, such as idelalisib. You should keep Trulance tablets in the container it came in, tightly closed and out of reach of children.

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