Domperidone (Motilium) is a prescription medication that increases the motility of the stomach and bowel. Domperidone may be used to manage nausea and vomiting associated with dopamine agonists used in Parkinson's disease, but only under strict specialist supervision and heart monitoring. Motilium contains the active ingredient domperidone, a well-known antiemetic and a prokinetic agent. It is a dopaminergic blocker that works by increasing the lower oesophagus sphincter pressure and activating gastric motility. Other medications for the treatment of gastroparesis include: erythromycin, metoclopramide, Resolor
Manufacturer Information
We currently have the brand Motilium from New Zealand, manufactured by Janssen. The generic comes from Canada by Pharmaris Canada (known as PRZ-Domperidone) and India (also called Vomistop by Cipla). It is available in the strength of 10 mg tablets.
You should follow the instructions of the doctor who prescribed Motilium to you. Directions and dosage information can also be found on the pack or leaflet inside the pack. Motilium comes in tablet form. You should swallow Motilium whole with a glass of water. For the best results, Motilium should be taken 15 to 30 minutes before meals. Taking it after food may delay its absorption and reduce its effectiveness. Motilium should be stored at room temperature away from direct sunlight and heat.
Contact your doctor if you experience these common side effects of Motilium and they are severe or bothersome.
• Anxiety
• Breast pain or tenderness
• Diarrhea
• Drowsiness or sleepiness
• Headache
• Itchy skin or rash
• Loss of libido (reduced sex drive in men)
• Unusual breast milk production (in both men and women)
• Weakness or tiredness
Less Common Side Effects:
• Dry Mouth
Stop taking the medication and see your doctor immediately if any of the following occur:
• Allergic reaction (signs include swelling of the face, lips, or throat, difficulty breathing, or severe hives)
• Extrapyramidal effects (uncontrolled movements such as eye rolling, unusual tongue movements, or twisted neck posture)
• Heart rhythm disorders (fast, pounding, or irregular heartbeat; fainting or severe dizziness)
• Seizures (fits)
• Urinary retention (inability to urinate or pain while urinating)
Please notify your doctor or pharmacist for advise if you are experiencing any severe adverse effects.
Before taking Motilium, consult your doctor to ensure your heart is healthy enough for this treatment. Do not use Motilium if you have pre-existing heart rhythm disorders or if you take medications that prolong the QT interval, as the combination can lead to life-threatening heart rhythm disturbances. Domperidone is associated with an increased risk of serious cardiac adverse events. It should be used at the lowest effective dose for the shortest possible time, typically not exceeding one week. There may be interactions between domperidone and other medications, including amiodarone, Clarithromycin, Erythromycin, Fluconazole, Itraconazole, Ketoconazole, Ritonavir, and Verapamil.
Dietary and Lifestyle Factors
While Motilium can be taken with or without food, taking it approximately 15 to 30 minutes before a meal may improve its effectiveness in aiding stomach emptying. However, you should avoid grapefruit and grapefruit juice, as they can interfere with the enzymes responsible for breaking down the drug, potentially leading to increased levels in the bloodstream and a higher risk of heart-related side effects. Additionally, it is wise to limit alcohol consumption, as alcohol can exacerbate gastrointestinal irritation and increase the likelihood of drowsiness or dizziness. For the best results, maintain a balanced diet and stay hydrated, as recent 2025 clinical perspectives emphasize that managing underlying digestive health through lifestyle adjustments supports the long-term efficacy of motility agents.
• Where can I buy Motilium online?
You can buy Motilium online from our certified Canadian Pharmacy, or by email (CustomerService@canadianpharmacyking.com), by phone (1-877-745-9217), or by fax or mail.
• Is Motilium available in generic form?
We carry a range of generic Motilium from Canada and India.
• Do I need a prescription to buy Motilium?
A prescription is required to purchase Motilium from a CIPA-verified Canadian pharmacy.