Motegrity (Prucalopride) is used to treat chronic idiopathic constipation (CIC). Motegrity is a selective serotonin type 4 (5-HT4) receptor agonist. Motegrity works by improving how well your stomach and intestines move food through the bowels during digestion. It binds with 5-HT receptors in the colon. By activating these receptors, the colon releases acetylcholine. An increase of acetylcholine increases something called colonic peristalsis, which is the reflexive contraction and release of the colon muscles. This allows for an increase of bowel mobility, and a decrease in constipation. This medication is typically only used when other medications have been ineffective.
Canadian Pharmacy King currently offers the brand Motegrity also called Resotran from Canada and Resolor from Singapore by Janssen-Cilag and Resolor from United Kingdom by Shire in the strength of 1 mg and 2 mg tablets. There is no generic available for this medication.
The common side effects of Motegrity include nausea, vomiting, or diarrhea, stomach pain, bloating or gas, headache or dizziness, or drowsiness. Stop using this medication and contact your doctor if you notice more serious side effects such as unusual changes in mood or behaviour, ongoing or worsening depression, or thoughts of suicide. If you notice any serious side effects or signs of an allergic reaction, seek emergency medical attention.
You should not use Motegrity if you are allergic to prucalopride, or if you have a blockage in your intestines, severe constipation, inflammatory bowel disease, toxic megacolon, or a perforation of your intestines. To make sure Motegrity is safe for you, tell your doctor if you have ever had kidney disease, depression, a mood disorder, or suicidal thoughts. Tell your doctor if you are pregnant or breast-feeding. Motegrity is not approve for use by anyone under the age of 18.
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