Before taking this medication, inform your doctor if you have severe liver or kidney problems, metabolic acidosis, serious infection, had a recent heart attack or stroke, have vitamin B12 or folic acid deficiency, drink alcohol and have severe dehydration.Glumeta may rarely be associated with a serious, life-threatening condition called lactic acidosis. You should not drink a lot of alcohol if you take Glumetza. Do not take Glumetza if you are allergic to metformin or any other ingredients in this medication, have unstable or type 1 (insulin dependent) diabetes, acute or chronic metabolic acidosis or diabetic ketoacidosis, history of lactic acidosis, severe liver problems, heart problems, kidney disease, drink alcohol, are going to have an X-ray procedure with injection of iodinated contrast materials, are going to have surgery, have a severe infection, have severe dehydration (lost a lot of fluid from the body), are pregnant or planning to become pregnant. Glumetza may interact with medications such as other diabetes drugs, such as glyburide, insulin, and rosiglitazone, medications that may increase blood sugar levels like ‘water pills’ (diuretics), birth control pills, decongestants, thyroid medicines, prednisone (corticosteroid drugs), phenytoin, nicotinic acid, certain drugs which control high blood pressure (e.g. calcium channel blockers), and isoniazid, furosemide, nifedipine, cationic drugs which may interfere with the elimination of metformin (e.g. cimetidine, amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamterene, trimethoprim, vancomycin), certain ‘blood thinners’ (coumarin-type anticoagulants), alcohol.