Zyban (Bupropion) is used as nonnicotine aid to smoking cessation in nicotine-dependent adult patients, only in combination with motivational support. Zyban (Bupropion) elevates the level of some of brain chemicals (neurotransmitters such as dopamine, norepinephrine, serotonin), which may contribute to its ability to suppress craving to smoking. Zyban (Bupropion) should be used in accordance with smoking cessation guidelines.
Zyban (Bupropion) startet at 150 mg to be taken once daily in the morning for three days, increasing on day four to 150mg twice daily for 7-12 weeks. There should be an interval of at least 8 hours between successive doses. It is recommended that treatment is started while the patient is still smoking and a "target stop date" set within the first two weeks of treatment with Zyban, preferably in the second week. The maximum single dose must not exceed 150mg and the maximum total daily dose must not exceed 300mg. Zyban tablets should be swallowed whole and not crushed or chewed.
Commonly reported adverse reactions with Zyban (Bupropion) are: dizziness, headache, sleep disturbance, anxiety, agitation, euphoria, depression, impaired memory, increased risk of seizure, tremor; nausea, dry mouth; blurred vision, chest pain, palpitations, flushing, changes in blood pressure, syncope; skin rash; decreased libido, menstrual irregularities; urinary frequency.
Zyban (Bupropion) should not be used in patients with seizure or with history of seizure. Zyban is also not indicated in those with history of eating disorder such as bulimia or anorexia nervosa. Use causiously if you have high blood pressure, or heart disease. Zyban may influence patient's ability to drive and use machines. It may also potentiate the effects of alcohol and CNS depressants (such as sleeping tablets, antidepressants, antipsychotics, and antiallergy medications). Use cautiously with these drugs and do not take with alcohol. Zyban is not indicated in patients younger than 18 years of age. If at seven weeks of treatment no effect is seen, treatment is recommended to be discontinued on your doctor's advise.