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Zofran Oral Solution (Ondansetron Hydrochloride Dihydrate)

Drug:Zofran Oral Solution (Expiry Note)
Dosage:4 mg/5 ml/50 ml

Zofran belongs to the group of medications called antiemetics. Zofran is used for the prevention of nausea (feeling of sickness) and vomiting during treatment for cancer (chemotherapy and radiotherapy) and for the prevention and treatment of nausea and vomiting after surgery. Treatments such as general anesthesia, cancer chemotherapy and radiotherapy are thought to cause the release of a natural substance (serotonin), which can cause you to feel sick and to vomit. Zofran helps to stop this from happening, thus preventing you from vomiting or feeling sick. Do not take more doses, or take them more often than your doctor prescribes. If, however, you vomit within one hour of taking your medicine, you should take the same amount of medicine again. If vomiting persists, consult your doctor. Ondansetron can be taken with or without food. Follow your doctor's dosing instructions very carefully. Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.

Manufacturer Information

Canadian Pharmacy King currently offers Zofran Oral Solution from Canada manufactured by GSK. Our Canadian Pharmacy also offers the generic Zofran Oral Solution also called Ondansetron from Canada by a different manufacturer. Zofran Oral Solution is available in the strength of 4 mg/5 ml/50 ml.

The common side effects of Zofran may include headaches, a feeling of warmness, flushing or constipation, nausea, vomiting. Contact your doctor right away if you have any of the following symptoms:

• blurred vision or temporary vision loss;

• fast or pounding heartbeats;

• headache with chest pain and severe dizziness, fainting, fast or pounding heartbeats;

• high levels of serotonin in the body--agitation, hallucinations, fever, fast heart rate, overactive reflexes, loss of coordination, fainting;

• jaundice (yellowing of the skin or eyes);

• severe constipation, stomach pain, or bloating

This is not a complete list of side effects and others may occur. Please call your doctor if you have any further concerns or questions.

Do not take Zofran Oral Solution if you have a history of hypersensitivity (an allergic reaction) to any ingredient in Zofran or if you are taking apomorphine (used to treat Parkinson’s disease). Before you use Zofran, talk to your doctor or pharmacist if you: have a history of hypersensitivity (an allergic reaction) to any ingredient in Zofran, have had an allergic reaction to medicines similar to Zofran, are pregnant or are breast feeding, have liver problems, have signs of intestinal obstruction, have a history of heart problems. If you experience wheezing and tightness of the chest, heart throbbing, swelling of eyelids, face or lips, or develop a skin rash, skin lumps or hives, contact your doctor immediately. Do not take any more medicine unless your doctor tells you to do so. Serotonin Syndrome is a rare but potentially life-threatening reaction that may occur if you take Zofran with certain other medications. Be sure to tell your healthcare professional about all the medicines you are taking, including those prescribed by other doctors, vitamins, minerals, natural supplements or alternative medicines.

Tell your doctor if you are taking: carbamazepine, phenytoin, or rifampicin, any medicines containing tramadol, drugs used to treat heart rhythm disorders, antipsychotics, antidepressants, antibiotics or antifungals, opiod analgesics (painkillers), other drugs to treat nausea and vomiting, asthma drugs, cancer drugs, diuretics, drugs that affect serotonin including medicines used to treat depression, anxiety, Parkinson’s Disease, drugs that contain tryptophan, or St. John’s Wort. Store Zofran Oral Solution in its bottle, upright between 15 and 30°C. Do not refrigerate.

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