Zestoretic (Lisinopril and Hydrochlorothiazide) is used to treat hypertension (high blood pressure) and fluid retention. Zestoretic contains two medications, hydrochlorothiazide and lisinopril. Hydrochlorothiazide belongs to a class of medications called thiazide diuretics (water pills) and works by preventing your body from absorbing too much salt, which can cause fluid retention. Lisinopril is an ACE (angiotensin converting enzyme) inhibitor, and works by decreasing certain chemicals that tighten the blood vessels, so blood flows more smoothly and the heart can pump blood more efficiently. Together, these medications can reduce strain on the heart and lower blood pressure, which in turn can lower your risk of stroke or heart attack.
Canadian Pharmacy King currently offers the brand Zestoretic from Canada by AstraZeneca. The generic Lisinopril/HCTZ is available from the United Kingdom and Canada by different manufacturers. Zestoretic and the generic Lisinopril/HCTZ is available in the strength of 10 mg/12.5 mg, 20 mg/12.5 mg, and 20 mg/25 mg tablets.
Common side effects of Zestoretic may include cough, dizziness, headache, or tired feeling.
Contact your doctor immediately if you notice more serious side effects such as:
• A light-headed feeling, like you might pass out;
• Eye pain, vision problems;
• Fever, chills, sore throat, mouth sores, trouble swallowing;
• Jaundice (yellowing of the skin or eyes);
• Signs of high potassium (nausea, tingly feeling, chest pain, irregular heartbeats, loss of movement);
• Signs of low potassium (leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling);
• Signs of low sodium (headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady);
• Weakness, drowsiness, or feeling restless
This is not a complete list of side effects. If you notice any other side effects not listed here, please contact your doctor or pharmacist.
You should not use Zestoretic if you are allergic to hydrochlorothiazide or lisinopril, or if:
• You are unable to urinate;
• You have an allergy to sulfa drugs;
• You have ever had an allergic reaction to any ACE inhibitor;
• You have hereditary angioedema
To make sure Zestoretic is safe for you, tell your doctor if you have ever had kidney disease or if you are on dialysis, cirrhosis or other liver disease, glaucoma, heart disease or congestive heart failure, asthma or allergies, gout, lupus, or if you are on a low-salt diet. Do not use this medication if you are pregnant. Stop using this medication and tell your doctor immediately if you become pregnant. Lisinopril can cause injury or death to the unborn baby if you take the medication during our second or third trimester. You should not breastfeed if you are taking Zestoretic. This medication is not approved for use by anyone younger than 18 years old. Hydrochlorothiazide may increase your risk of skin cancer. Avoid sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors. Your doctor may want you to have skin examinations on a regular basis. Drinking alcohol can further lower your blood pressure and may increase certain side effects of this medicine. Avoid drinking alcohol while taking this medication. Do not use potassium supplements or salt substitutes while you are taking this medicine, unless your doctor has told you to.
Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Avoid becoming overheated or dehydrated during exercise, in hot weather, or by not drinking enough fluids. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough. Several medications may interact with Zestoretic, especially other blood pressure medications, lithium, everolimus, sirolimus, temsirolimus, or nonsteroidal anti-inflammatory drugs (NSAIDs). This is not a complete list of interactions and others may occur. Tell your doctor about any medications, vitamins, or herbal supplements you are currently taking or have recently taken in order to reduce the risk of any possible interactions.
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