This medication is used to treat major depressive disorder (MDD) and to prevent seasonal affective disorder (SAD), often referred to as autumn-winter seasonal depression. Bupropion is an atypical antidepressant that works as a norepinephrine-dopamine reuptake inhibitor (NDRI). It affects mood by balancing these naturally occurring chemicals in the brain. The full therapeutic effects of the medication may not be seen until after several weeks of treatment. For the treatment of MDD, the initial dose of 150 mg once daily should be taken for three days. If the medication is well-tolerated, the dosage may be increased to the target dose of 300 mg once daily starting on the fourth day of treatment."
Building on bupropion's long-standing clinical profile, recent clinical evaluations continue to support its versatility in mental health. In a 2025 study published in the International Journal of Molecular Sciences titled "Efficacy and Tolerability of Bupropion in Major Depressive Disorder with Comorbid Anxiety Symptoms: A Systematic Review," researchers conducted a meta-analysis of approximately 3,700 patients to evaluate the drug's performance in treating anxious depression. The study concluded that bupropion XL provides a "clinically relevant improvement" in anxiety symptoms for adults with MDD, with efficacy comparable to SSRIs while maintaining its unique advantage of lower rates of sexual dysfunction and weight gain. While this medication can be effective for patients with major depressive disorder and comorbid anxiety symptoms, it is important to note that bupropion has stimulating properties. Anxiety, agitation, and restlessness are common side effects reported by a significant number of patients, particularly during the initial weeks of treatment.
Manufacturer Information
We currently have the brand from Turkey and the brand from Canada, both manufactured by Bausch Health (formerly Valeant). The generic Bupropion XL is available from Actavis or Mylan in Canada. It may also originate in India and be manufactured by Sun Pharma (also marketed as Bupron XL).
Wellbutrin XL is available in 150 mg and 300 mg tablets. Its costs vary depending on the brand, dosage, quantity, and the country of origin. Canadian Pharmacy King is an accredited online pharmacy that offers this medication at a lower cost than the average U.S. retail price. Other medications for the treatment of depression include
Zoloft and
Paxil.
The information below lists potential side effects and risks. It is crucial to discuss these with your doctor or pharmacist.
Common Side Effects – The following are common side effects of Wellbutrin XL. Contact your doctor if you experience these side effects and they are severe or bothersome.
• Abdominal pain
• Agitation or restlessness
• Anxiety
• Constipation
• Dizziness
• Dry mouth
• Headache
• Insomnia (trouble sleeping)
• Nausea
• Sore throat
• Sweating
• Tremors (shaking)
• Weight loss
Other Potential Side Effects: (less common) - These effects are reported less frequently but can still occur:
• Blurred vision
• Change in sense of taste
• Drowsiness
• Frequent urination
• Hot flashes
• Muscle or joint aches
• Palpitations (fast heartbeat)
• Ringing in the ears (tinnitus)
• Skin rash or itching
• Unusual feeling of well-being
Serious Side Effects - These are rare but potentially severe. Seek your doctor or call medical emergency services immediately if any of the following occur:
• Anaphylaxis (severe allergic reaction, including swelling of the face, tongue, or throat)
• Angle-Closure Glaucoma (eye pain, vision changes, or seeing halos)
• Chest pain
• Hypertension (severe high blood pressure)
• Manic episodes (racing thoughts, reckless behavior, or extreme energy)
• Psychosis (hallucinations, paranoia, or delusions)
• Seizures (convulsions or fits)
• Suicidal ideation (thoughts of self-harm, especially in young adults)
Do not use Wellbutrin XL if you have a known allergy to bupropion hydrochloride or any inactive ingredients. This medication is strictly contraindicated if you have a seizure disorder, a current or prior diagnosis of bulimia or anorexia, or if you are currently undergoing abrupt withdrawal from alcohol, benzodiazepines, or sedatives. Additionally, do not use this medication if you have taken a Monoamine Oxidase Inhibitor (MAOI) within the last 14 days.
Dietary and Lifestyle Factors
To optimize the therapeutic benefits of Wellbutrin XL, patients should manage several key dietary and lifestyle factors. Primarily, it is critical to limit or avoid alcohol, as it significantly increases the risk of seizures and may worsen neuropsychiatric side effects such as paranoia or mood swings. Similarly, excessive caffeine intake should be monitored, as bupropion's stimulating effects can heighten jitteriness, raise blood pressure, and cause insomnia. Maintaining a consistent routine is vital; patients must avoid abruptly stopping alcohol or sedatives (like benzodiazepines), which can dangerously lower the seizure threshold. For optimal outcomes, the medication should be taken in the morning to prevent sleep disturbances. It can be taken with or without food, but a meal may help mitigate nausea. Finally, avoiding herbal supplements like St. John's Wort is recommended to prevent adverse drug-herbal interactions.
How do I buy Wellbutrin XL?
You can buy this medication online from our certified Canadian Pharmacy, or by email (CustomerService@canadianpharmacyking.com), by phone (1-877-745-9217), or by fax or mail.
Is Wellbutrin XL available in generic form?
We carry a range of generic bupropion hydrochloride 24-hour ER tablets from Canada.
Is a prescription required to purchase Wellbutrin XL?
A prescription is required when purchasing from a CIPA-verified Canadian pharmacy.
How much does Wellbutrin XL cost?
Its costs vary by brand, dosage, quality, and country of origin. At Canadian Pharmacy King, we are proud to offer highly competitive prices.
What is the copay or coinsurance for Wellbutrin XL?
We do not accept insurance for this medication; insurance-based cost-sharing models, such as copayments or coinsurance, do not apply. Patients are responsible for the full listed price of the medication at the time of purchase.