Vtama (Tapinarof) is a prescription medication used for the topical treatment of plaque psoriasis in adults and atopic dermatitis (eczema) in adults and children 2 years of age and older. Plaque psoriasis is an immune-mediated disease characterized by the overgrowth of skin cells. Atopic dermatitis is a chronic inflammatory condition that causes itchy, inflamed skin. The active ingredient in Vtama is Tapinarof. It belongs to a class of medications known as aryl hydrocarbon receptor (AhR) agonists. It works by binding to and activating the AhR, a protein that helps maintain skin homeostasis. This activation leads to downregulation of pro-inflammatory cytokines (such as IL-17) and helps restore the skin's natural barrier by inducing the expression of essential proteins, such as filaggrin.
Manufacturer Information
We currently offer the brand Vtama, manufactured in Canada by Organon, in the strength of 1% cream, 60 gm. The generic Tapinarof is currently unavailable.
Get medical help immediately if you have any of these signs or an allergic reaction while using Vtama. The most common side effects of Vtama may include the following:
• Contact dermatitis (allergic skin reaction);
• Folliculitis (inflamed, red, or pained hair follicles);
• Headache;
• Influenza or flu-like symptoms;
• Nasopharyngitis (inflammation of the nose and throat);
• Pruritus (itching)
Contact your doctor right away if you have any of the severe side effects, including:
• Severe skin rash, peeling, or stinging at the application site;
• Signs of a secondary skin infection (e.g., pus-filled follicles or fever)
These are not all of Vtama's side effects. Always contact your doctor if you notice any unusual symptoms.
You should not use Vtama if you are allergic to tapinarof or any of its ingredients. Before you start using this medication, tell your doctor about your medical history, especially if you:
• Are breastfeeding or planning to breastfeed;
• Are pregnant or planning to become pregnant;
• Have a history of frequent skin infections.
Tell your doctor about all your medications, including prescription, OTC, herbal supplements, and vitamins. While drug interactions with systemic medications are less likely due to low absorption, using other topical treatments on the same area of skin as Vtama may require spacing out applications.
Tell your doctor if you are pregnant or planning to become pregnant. It is unknown if Vtama will harm an unborn baby, as there is insufficient human data. Inform your doctor if you are breastfeeding or planning to breastfeed. It is unknown whether tapinarof passes into human breast milk. If breastfeeding, do not apply the cream directly to the nipple or areola to avoid infant contact.
Use this medicine exactly as your doctor prescribes it. Vtama is applied to the skin. Do not take it by mouth. Avoid contact with the eyes, mouth, or vagina. Apply a thin layer to the affected areas only once daily. Wash your hands immediately after application, unless your hands are the area being treated. Apply the medication at the same time each day to maintain consistency. Vtama may be used on sensitive areas such as the face, neck, and skin folds, as directed by a doctor.
Store Vtama at room temperature, between 20°C and 25°C (68°F and 77°F). Do not freeze or expose the tube to excessive heat. Keep the medication out of the reach of children.