Take Vimovo exactly as prescribed by your healthcare professional. Vimovo should be taken at least 30 minutes before a meal. The tablets should be swallowed whole with water. Do not crush, chew or split the tablets. Do not take more of it. Do not take it more often, and do not take it for a longer period than recommended be your doctor. Vimovo may cause you to become drowsy or tired. If you become drowsy, dizzy or light-headed after taking Vimovo, do not drive or use machines. Vimovo may cause you to become more sensitive to sunlight. Sunlight or sunlamps may cause sunburn, skin blisters, skin rash, redness, itching or discolouration, or vision changes. If you have a reaction from the sun, check with your health care provider. Do not use the medication if you are allergic to naproxen, esomeprazole or any other ingredients in the medication, are planning to have or had heart bypass surgery, have severe uncontrolled and severe heart failure, have bleeding in the brain, are pregnant or breastfeeding, have an active ulcer, have liver or kidney disease, have inflammatory bowel disease, have high potassium in blood or are taking rilpivirine. This medication should not be used in patients under 18 years of age. Vimovo may interact with medications such as acetylsalicylic Acid (ASA) or other NSAIDs (e.g. celecoxib, indomethacin, ketorolac), antacids, antidepressants, blood pressure medications, blood thinners (e.g. warfarin, ASA, clopidogrel), corticosteroids (including glucocorticoids e.g. prednisone), cyclosporine, digoxin, diuretics (e.g. furosemide, hydrochlorothiazide), erlotinib (or any other anticancer drug from the same class), lithium, methotrexate, oral contraceptives, oral hypoglycemics (diabetes medications), tacrolimus. Before taking this medication, inform your doctor if you have high blood pressure, high cholesterol, diabetes, atherosclerosis, kidney or urine problems, ulcers, have a family history of asthma, nasal polyps, long-term swelling of the sinus, or are planning to become pregnant.