Sprycel is used to treat adults who have newly diagnosed Philadelphia chromosome positive (Ph+) chronic myeloid leukemia (CML) in chronic phase (a type of cancer), Ph+ CML who are no longer benefiting from other available therapies for CML, including imatinib mesylate (Gleevec) and to treat a particular form of Ph+ acute lymphoblastic leukemia (ALL). CML is a type of leukemia. In CML, white blood cells multiply in an uncontrolled manner. It can take many years for CML to progress because it is a slow-growing and chronic cancer. There are three phases of CML: chronic phase, accelerated phase, and blast crisis phase. As CML progresses, patients advance through these phases. Ph+ acute lymphoblastic leukemia or Ph+ ALL is another form of leukemia. Acute leukemias progress faster than chronic leukemias. In Ph+ ALL, lymphoblastic white blood cells multiply in an uncontrolled manner. The active ingredient of Sprycel is dasatinib. Dasatinib acts by inhibiting the activity of proteins within the leukemia cells of patients with CML. These proteins are responsible for the uncontrolled growth of the leukemia cells. Take the medication exactly as prescribed by your doctor. The usual dose for chronic phase CML is 100 mg once a day either in the morning or in evening. The tablets should be swallowed whole, not crushed. They can be taken with or without food. Try to take Sprycel at the same time each day.
The brand Sprycel comes from Turkey and Canada manufactured by Bristol-Myers Squibb. There is no generic available for this medication. Sprycel is available in the dosages of 20 mg, 50 mg, 70 mg, 80 mg, 100 mg and 140 mg.
Sprycel Side Effects
Stop taking Sprycel and call your doctor at once if you have one of these serious side effects:
• Low blood counts;
• Bleeding or bruising without having any injury;
• Blood in vomit, stools or urine;
• Fluid retention;
• Liver toxicity;
• Irregular heartbeat;
• Increase in blood pressure in the arteries supplying blood to the lungs;
• Severe skin reactions like Stevens-Johnson Syndrome
Less serious side effects include dizziness, diarrhea, fever, headache, fatigue, nausea, skin rash, shortness of breath, cough, vomiting, pain, stomach pain, infection, upper respiratory tract infection, muscle aches, joint aches, and bone and extremity pain. Please call your doctor if you have any further concerns or questions.
This is not a complete list of side effects and others may occur. Please call your doctor if you have any further concerns or questions.
Avoid taking grape fruit juice since it may increase the blood levels of Sprycel. Do not take Sprycel if you have or had allergy to dasatinib or any other ingredients in the medication. Do not breastfeed while taking Sprycel. Sprycel should not be used in children under 2 years of age. Sprycel may interact with antibiotics such as ketoconazole, itraconazole, erythromycin, clarithromycin, dexamethasone (a corticosteroid), rifampicin (used to treat tuberculosis), anti-epileptics such as carbamazepine and phenobarbital, cyclosporine (used to prevent organ rejection after transplant), simvastatin (used to lower cholesterol levels), blood thinners such as warfarin, antacids such as cimetidine, famotidine, ranitidine, or omeprazole, magnesium hydroxide.
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