The following Repronex side effects,were reported during menotropins therapy, are listed in decreasing order of potential severity:
Pulmonary and vascular complications
Ovarian Hyperstimulation Syndrome
Adnexal torsion (as a complication of ovarian enlargement)
Mild to moderate ovarian enlargement
Sensitivity to menotropins (Febrile reactions suggestive of Repronex side effects have been reported following the administration of menotropins. Reports of Repronex side effects like flu-like symptoms including fever, chills, musculoskeletal aches, joint pains, nausea, headaches, and malaise have also been reported).
Gastrointestinal symptoms (nausea, vomiting, diarrhea, abdominal cramps, bloating)
Pain, rash, swelling and/or irritation at the site of injection
Dizziness, tachycardia, dyspnea, tachypnea
The following Repronex side effects have been reported subsequent to pregnancies resulting from menotropins therapy:
With menotropin therapy congenital abnormalities have been reported. One infant was shown to have multiple congenital anomalies consisting of aplasia of the sigmoid colon, cecovesicle fistula, bifid scrotum, meningocele, bilateral internal tibial torsion, and right metatarsus adductus. Other reported Repronex side effects include imperforate anus, congenital heart lesions, supernumerary digits, hypospadias, extrophy of the bladder, Down's syndrome and hydrocephalus. The incidence of congenital abnormalities does not exceed that found in the general population.
There have been infrequent reports of Repronex side effects like ovarian neoplasms, both benign and malignant, in women who have undergone multiple drug regimens for ovulation induction; however, a causal relationship has not been established.
Repronex is contraindicated in women who have: A high FSH level indicating primary ovarian failure, Uncontrolled thyroid and adrenal dysfunction, An organic intracranial lesion such as a pituitary tumor, the presence of any cause of infertility other than anovulation unless they are candidates for in vitro fertilization, Abnormal bleeding of undetermined origin, Ovarian cysts or enlargement not due to polycystic ovary syndrome.
Prior hypersensitivity to menotropins. Repronex is not indicated in women who are pregnant. There are limited human data on the Repronex side effects when administered during pregnancy.