You should not use Provera if you are allergic to medroxyprogesterone, or if you have abnormal vaginal bleeding that has not been diagnosed, a hormone-related cancer such as breast or uterine cancer, liver disease, or a history of stroke or blood clot. To make sure Provera is safe for you, tell your doctor if you have ever had heart disease, congestive heart failure, recent stroke or heart attack, high blood pressure, high cholesterol or triglycerides, low levels of calcium in your blood, severe pelvic pain, recent marriage or abortion, epilepsy, asthma, migraine headaches, a thyroid disorder, kidney disease, diabetes, or lupus. Do not take this medication if you are pregnant, as it can cause complications in the unborn baby. Tell your doctor immediately if you become pregnant while using this medication. Provera can pass into breast milk and may harm a nursing baby. Talk to your doctor if you are breastfeeding to discuss any possible risks.
Provera will not prevent heart disease, breast cancer, or dementia, and may increase the risk of developing these conditions in post-menopausal women. This medication may also increase the risk of uterine or ovarian cancer in some women. Long-term treatment with estrogens and progestins may also increase your risk of heart attack, blood clot, or stroke. Avoid smoking while you are taking Provera, as smoking can greatly increase your risk of blood clots. This medication is not approved for use by anyone under the age of 18. Provera may interact with several medications, especially acitretin, brigatinib, darunavir, idelalisib, ivacaftor, lesinurad, nelfinavir, ritonavir, saquinavir, telithromycin, and voriconazole. This is not a complete list of interactions, and others may occur. Tell your doctor about any medications, vitamins, or herbal supplements you are currently taking or have recently taken in order to reduce the risk of any possible interactions.
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