Pregnancy should be avoided while taking Prograf because it may cause fetal abnormalities and malformations. Breast-feeding is not recommended while taking Prograf. Prograf may cause new onset diabetes in kidney transplant patients. Do not take Prograf if you are hypersensitive to tacrolimus or to any of the ingredients in the formulation, including castor oil, are pregnant or trying to become pregnant, are breastfeeding. Before taking Prograf, inform your doctor if you are getting any vaccinations or immunizations, have taken Prograf, FK506 or tacrolimus before and had a bad, unusual or allergic reaction, have heart problems, have a rare hereditary disease of galactose intolerance. Tell your doctor, nurse, or pharmacist about all the medicines you take, including drugs prescribed by other doctors, vitamins, minerals, natural supplements, or alternative medicines. In particular, you should tell your doctor if you are taking or have recently taken medicines such as antacids, antiarythmic: amiodarone, antifungals: clotrimazole, fluconazole, anticonvulsants: phenytoin, anti-infectives: rifampin, calcineurin inhibitor: sirolimus, cytomegalovirus (CMV) antivirals: letermovir, calcium channel blockers: diltiazem, nicardipine, verapamil, gastrointestinal prokinetic agents: cisapride, macrolide antibiotics: erythromycin, clarithromycin, troleandomycin, other drugs: bromocriptine, chloramphenicol, cyclosporine, danazol, protease inhibitors, proton pump inhibitors, potassium sparing diuretics. Prograf is not indicated for the use of rheumatoid arthritis in children younger than 18 years of age. Do not take Prograf with grapefruit or grapefruit juice.
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