(Diclofenac topical solution)
Pennsaid®, the first medication based on the company's patented transcellular technology, is used to treat osteoarthritis pain and stiffness. The drug combines a proprietary carrier with diclofenac sodium, a leading nonsteroidal anti-inflammatory drug (NSAID), and delivers active ingredient through the skin directly to the pain site. After many clinical studies, Pennsaid® lotion has not been linked to the problems often found with conventional NSAID treatment.
How should I use this medication?
The usual dose of diclofenac topical solution is 40 drops applied to the knee four times daily at evenly spaced time intervals. Apply it only to clean, dry skin.
Squeeze 10 drops of diclofenac topical solution into the hand or directly onto the knee.
Spread the solution evenly around the front, back, and sides of the knee.
Repeat this procedure until 40 drops have been applied and the knee is completely covered.
To treat the other knee, repeat the procedure.
Allow several minutes for the medication to dry.
Wash hands after applying the medication, and avoid contact with eyes or mucous membranes.
Do not apply the medication to infected, abraded, or open skin. Do not use dressings that do not breathe on top of this medication. This medication is for external use only, and should not be taken by mouth. The topical solution should not be used for longer than three months.
Many things can affect the dose of medication that a person needs, such as the severity of the condition, body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
It is very important that this medication be used on a regular schedule exactly as prescribed by your doctor. If you miss a dose of this medication, apply it as soon as you remember it. If it is almost time for your next dose, skip the missed dose and carry on with your regular schedule. Do not take a double dose to make up for a missed one.
When used regularly, NSAID pills can cause numerous side effects. The most severe are ulcers and gastrointestinal bleeding, but they can also include blood pressure increases, dizziness, headache, depression and delayed stomach emptying.
Pennsaid Side Effects
With topically applied Pennsaid®, the most common adverse reaction has been mild dryness or irritation at the application site. A recent equivalence study has also shown that Pennsaid® works as well as the maximum daily dose of oral diclofenac, without provoking serious side effects.
Are there any other precautions or warnings for this medication?
Hepatic porphyria: People with hepatic porphyria should use this medication with caution, as it may trigger an attack.
Infection: This medication may mask some of the signs of infection.
Kidney function: People with reduced kidney function may need lower doses and more frequent medical check-ups while using this medication.
Occupational hazards: Some people have reported headache, dizziness, lightheadedness, and confusion while taking this medication. Avoid operating motor vehicles and doing other potentially hazardous activities until you have determined the effect this medication has on you.
Stomach: Stomach ulcers and bleeding from the stomach have been known to occur when diclofenac is taken by mouth. These complications can occur at any time and are sometimes severe enough to require immediate medical attention. Although these reactions have not been seen with diclofenac topical solution, you should seek medical attention right away if you notice any signs of bleeding (such as dark, tarry stools, blood in the stools, or vomiting of material that looks like coffee grounds).
Vision: Other medications in the same family as diclofenac may cause vision changes such as blurred or decreased vision. If you notice vision changes, stop using the medication and check with your doctor.
Pregnancy: This medication is not recommended for use during pregnancy, as its safety has not been established.
Breast-feeding: This medication should not be used by nursing mothers.
Children: Diclofenac is not recommended for children. The safety, effectiveness, and dosage of this medication for this age group have not been established.
Seniors: Seniors may have a higher risk of side effects with this medication. Seniors may need lower doses of this medication and more frequent medical check-ups.
What other drugs could interact with this medication?
The following medications may affect the way that diclofenac works or increase the risk of side effects:
corticosteroids (e.g., prednisone)
other NSAIDs (e.g., naproxen, indomethacin)
quinolone antibiotics (e.g., ciprofloxacin, levofloxacin, gatifloxacin)
Diclofenac may affect the way that the following medications work or increase the risk of side effects:
beta-adrenergic blockers (e.g., metoprolol, atenolol)
diuretics (water pills; e.g., spironolactone)
medications for diabetes (e.g., glyburide, metformin)
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
stop taking one of the medications,
change one of the medications to another,
change how you are taking one or both of the medications, or
leave everything as is.
An interaction between two medications does not always mean that you must stop taking one of them. In many cases, interactions are intended or are managed by close monitoring. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications that you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
The generic alternative is not manufactured by the company that makes the brand product.
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