Ondissolve (Ondansetron) is a prescription medication used to prevent nausea and vomiting caused by chemotherapy, radiation therapy, and surgery. Nausea and vomiting are unpleasant and often debilitating symptoms that can be a side effect of cancer treatments or surgical procedures. The active ingredient in Ondissolve is Ondansetron. Ondansetron belongs to a class of medications known as serotonin 5-HT3 receptor antagonists. It works by blocking the action of serotonin, a natural substance in the body that can trigger nausea and vomiting. By blocking these receptors in the brain's vomiting center and the gastrointestinal tract, Ondansetron prevents the signals that cause vomiting.
Manufacturer Information
We currently offer the brand Ondissolve from Canada, manufactured by Takeda, in strengths of 4 mg and 8 mg as an orally disintegrating film. The generic Ondansetron is currently unavailable (at this pharmacy).
Get medical help immediately if you have any of these signs or an allergic reaction while using Ondissolve. The most common side effects of Ondissolve may include the following:
• Constipation;
• Diarrhea;
• Dizziness;
• Fatigue;
• Headache
Contact your doctor right away if you have any of the severe side effects, including:
• QT prolongation;
• Serotonin syndrome;
• Signs of an allergic reaction, such as trouble breathing, hives, swelling of the face, lips, or throat
These are not all of Ondissolve's side effects. Always contact your doctor if you notice any unusual symptoms.
You should not use Ondissolve if you are allergic to Ondansetron or any ingredient in Ondissolve. Before you start using this medication, tell your doctor about your medical history, especially if you:
• Are breastfeeding or planning to breastfeed;
• Are pregnant or planning to become pregnant;
• Have a history of liver disease;
• Have an electrolyte imbalance;
• Have congenital long QT syndrome;
• Have heart problems;
• Have signs of intestinal obstruction or blockage
Tell your doctor about all your medications, including prescription, OTC, herbal supplements, and vitamins. There may be drug interactions between Ondissolve and other medicines, such as apomorphine, tramadol, rifampin, phenytoin, quinidine, chlorpromazine, citalopram, ketoconazole, fentanyl, and St. John's wort. Tell your doctor if you are pregnant or planning to become pregnant. Ondansetron may harm an unborn baby. If you can get pregnant, your doctor may ask you to take a pregnancy test before starting your treatment with Ondissolve. Use effective birth control while using this medicine. Inform your doctor if you are breastfeeding or planning to breastfeed. It is unknown if Ondansetron is excreted in breast milk or if it may harm a nursing infant. This medicine should be used when breastfeeding only if the benefits outweigh the risks.
Use this medicine exactly as your doctor prescribes it. Ondissolve is an orally disintegrating film. Place the film under the tongue to dissolve it. Your mouth should be empty before placing the film on your tongue with a dry finger. The dose and timing depend on the condition being treated. For chemotherapy, it's often taken 30 minutes before treatment begins. If you vomit within one hour of using Ondissolve, take another dose. If vomiting persists, contact your doctor. Store this drug at room temperature, away from moisture, heat, and light. Keep out of the reach of children.