This medication is a single-injection viscosupplement used to treat pain associated with knee osteoarthritis (OA). It also helps maintain the health of the knee's synovial fluid. Hyaluronate acts as a lubricant and shock absorber in the joint, helping the patient move the knee more smoothly with less pain. It is usually used in patients who have not responded to other treatments, such as acetaminophen, exercise, or physical therapy, and is injected into the affected joint.
A comprehensive systematic review (Intra-Articular Hyaluronic Acid for Knee Osteoarthritis: A Systematic Umbrella Review, 2025) continues to support intra-articular hyaluronic acid (IAHA) as a pivotal non-surgical intervention. Updated findings indicate that for patients with early-to-moderate osteoarthritis, this medication is a safe option with moderate efficacy for pain relief and functional improvement. This medication acts as a lubricant and shock absorber, providing temporary pain relief and improved joint mobility. While some research explores its potential to support joint health, it is primarily used for the symptomatic management of osteoarthritis pain.
Manufacturer Information
The brand Monovisc 4 ml Injection is available in Canada and Turkey and is manufactured by Anika.
There is currently no generic version available at this pharmacy.
Other medications for the treatment of knee pain associated with osteoarthritis (OA) include Synvisc and Orthovisc.
The information below lists potential side effects and risks. It is crucial to discuss these with your doctor or pharmacist.
Common Side Effects – The following are some common side effects of Monovisc. Contact your doctor if you experience any of these common side effects and they are severe or bothersome.
• Arthralgia (joint pain) at the injection site.
• Joint swelling or effusion.
• Local reaction such as redness or warmth.
• Stiffness in the treated knee.
Other Potential Side Effects: (less common) – These effects are reported less frequently but still have a chance to occur:
• Back pain.
• Dizziness.
• Headache.
• Myalgia (muscle pain)
• Nausea.
• Paraesthesia (a "pins and needles" sensation).
• Pruritus (itching) or a mild skin rash near the site.
Serious Side Effects: These are rare but potentially severe. Seek your doctor or call medical emergency services immediately if any of the following occur.
• Anaphylactic reactions (severe allergic responses, including swelling of the face, tongue, or throat and difficulty breathing).
• Infection at the injection site (septic arthritis), characterized by intense pain, fever, and severe inflammation.
• Severe localized skin reactions or hives (urticaria).
You should not use Monovisc if you have a known hypersensitivity to Hyaluronate, gram-positive bacterial proteins, or any of the inactive ingredients in the syringe. It is also contraindicated if you have an active infection or skin disease at the injection site. Before starting this treatment, discuss your full medical history with your healthcare provider, including any bleeding disorders or venous/lymphatic stasis in the legs. You must also disclose all current medications, including OTC and herbal supplements. Skin disinfectants containing quaternary ammonium salts (e.g., benzalkonium chloride) can precipitate medications; therefore, they should not be used for skin preparation. This medication is indicated only for the knee; its safety in other joints is unknown. After the injection, avoid strenuous or prolonged weight-bearing activities for 48 hours. It should not be used during pregnancy unless clearly needed. Because it is unknown whether the medication passes into breast milk, you should consult your doctor before breastfeeding.
Dietary and Lifestyle Factors
While this medication is a localized injection rather than an oral medication, there are specific lifestyle and activity factors that are critical to the treatment's success and your safety. Unlike many oral drugs, it does not have the systemic dietary restrictions or food-drug interactions typically associated with oral medications.
It is essential to avoid strenuous or prolonged weight-bearing activities—such as jogging, tennis, heavy lifting, or standing for long periods—for at least 48 hours after injection. This resting period allows hyaluronate to settle effectively within the joint capsule, significantly reducing the risk of post-injection pain or swelling.
Additionally, you should monitor the injection site for any local reactions. While staying hydrated is generally beneficial for joint health, maintaining a healthy body weight is emphasized in the recent 2025 clinical perspectives as a key factor in reducing the mechanical load on the knee. This combination of immediate post-procedural rest and long-term weight management optimizes joint mobility and helps the medication achieve optimal results.
How do I buy Monovisc?
You can buy this medication online from our certified Canadian Pharmacy, or by email (CustomerService@canadianpharmacyking.com), by phone (1-877-745-9217), or by fax or mail.
Is a prescription required to purchase Monovisc?
A prescription is required when purchasing from a CIPA-verified Canadian pharmacy.
Are there any discounts or financial assistance programs available for Monovisc?
Our Canadian pharmacy does not offer any discounts or financial assistance programs. At Canadian Pharmacy King, we are proud to offer highly competitive prices on this medication.
Can you walk or exercise after a Monovisc injection?
It is recommended that you refrain from high-level activities involving your knee for approximately 48 hours.