Migranal (Dihydroergotamine Mesylate) is a medication used to treat migraine headache attacks with or without aura in adults. Using this medication will help relieve headaches and other symptoms such as sensitivity to light or sound. Dihydroergotamine belongs to a class of drugs known as ergot alkaloids. It works by narrowing blood vessels in the brain. Treating your migraine headache will allow you to get back to your normal routine sooner and may decrease the need to take other pain medications. Migranal will only treat a headache that has already begun; it will not prevent headaches or reduce the number of migraine attacks. This medication should not be used to treat common tension headaches or any other types of headaches.

Manufacturer Information

Seek emergency medical help if you have any signs of an allergic reaction to this medication.

The common side effects of Migranal may include:
• Altered sense of taste;
• Diarrhea;
• Dizziness;
• Insomnia;
• Nausea, vomiting;
• Pain, bruising or irritation at the injection site;
• Soreness or irritation in your nose

Contact your doctor immediately if any of these serious side effects occur:
• Chest pain or tightness, shortness of breath;
• Diarrhea that may be bloody, stomach cramps;
• Leg weakness;
• Muscle pain in the arms or legs;
• Numbness or tingling fingers or toes;
• Signs of a blood clot;
• Swelling or itching

This is not a complete list of side effects and others may occur. Please call your doctor if you have any further concerns or questions.

Do not use Migranal if you are allergic to Dihydroergotamine Mesylate or to other similar medications or if you have had a vascular surgery or if you have:
• A history of a heart attack or stroke;
• An infection called sepsis;
• Heart problems (chest pain, coronary artery disease, blood circulation problems);
• Severe liver or kidney disease;
• Uncontrolled high blood pressure

Prior to taking this medication, tell your doctor about your medical history if you have ever had:
• Blood circulation problems in your arms, hands, legs, or feet;
• Chest pain, shortness of breath;
• Liver or kidney disease;
• Risk factors for coronary artery disease (high blood pressure, high cholesterol, diabetes, menopause, smoking, family history of coronary artery disease, are overweight and a man)

Some medications should not be used with Migranal; your doctor may need to change your treatment plan if you also use antibiotics (clarithromycin or erythromycin), antifungals (itraconazole or ketoconazole), or antiviral medications for HIV or hepatitis C. Do not use Migranal within 24 hours before or after using another migraine medication such as sumatriptan, rizatriptan, frovatriptan, ergotamine, etc. Tell your doctor about all the medications you take including prescription, nonprescription, herbal products, and vitamins. There may be a drug interaction between Migranal and other medications. Avoid grapefruit products; it may interact with Migranal and cause side effects. Consult your doctor if you are pregnant. You should not breastfeed while you are using this medication and for at least three days after your last dose.

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