Midrid (Acetaminophen/Isometheptene) is a prescription medication used to relieve migraine and tension-type headaches. A migraine is a type of headache characterized by intense, pulsating pain, often on one side of the head. It may be accompanied by nausea, vomiting, and sensitivity to light or sound. Tension-type headaches, on the other hand, cause a dull, constant pain or pressure around the forehead, the back of the head, and the neck, often linked to stress or muscle tension. The active ingredients in Midrid are Acetaminophen and Isometheptene. Acetaminophen belongs to a class of drugs called analgesics and antipyretics. It works on the hypothalamus to reduce fever and modulates pain perception by raising the pain threshold. Isomethepene belongs to a class of drugs called sympathomimetics or vasoconstrictors. During a migraine attack, the blood vessels in the brain dilate, increasing pain and pressure. By constricting these vessels, isometheptene helps relieve the throbbing, pulsating headache pain typical of migraines.
Manufacturer Information
We currently offer the brand Midrid from the United Kingdom in the strength of 325 mg/65 mg tablets. The generic Acetaminophen/Isometheptene is currently unavailable (at this pharmacy).
Get medical help immediately if you have any of these signs or an allergic reaction while using Midrid. The most common side effects of Midrid may include the following:
• Dizziness;
• Drowsiness;
• Dry mouth;
• Flushing;
• Nausea
Contact your doctor right away if you have any of the severe side effects, including:
• Irregular or pounding heartbeat;
• Signs of an allergic reaction, such as trouble breathing, hives, swelling of the face, lips, or throat;
• Signs of liver problems, including yellowing of the eyes or skin, dark urine, severe nausea, or pain in the upper right abdomen
These are not all of Midrid's side effects. Always contact your doctor if you notice any unusual symptoms.
You should not use Midrid if you are allergic to Acetaminophen/Isometheptene or any ingredient in Midrid. Before you start using this medication, tell your doctor about your medical history, especially if you:
• Are breastfeeding or planning to breastfeed;
• Are pregnant or planning to become pregnant;
• Have glaucoma;
• Have peripheral vascular disease;
• Have severe kidney problems;
• Have severe liver disease;
• Have uncontrolled or severe hypertension
Tell your doctor about all your medications, including prescription, OTC, herbal supplements, and vitamins. There may be drug interactions between Midrid and other medicines, such as phenelzine, phenylephrine, Tylenol, warfarin, diazepam, carbamazepine, etc. If you are taking an MAOI like isocarboxazid or phenelzine, do not use Midrid within 14 days of taking it. Tell your doctor if you are pregnant or planning to become pregnant. The safety and effectiveness of Midrid in pregnancy have not been fully established. This medicine should only be used during pregnancy if the benefits outweigh the risks. Inform your doctor if you are breastfeeding or planning to breastfeed. It is unknown if this medicine passes into breastmilk.
Use this medicine exactly as your doctor prescribes it. Midrid is available as tablets. Swallow the tablet whole with a glass of water. Do not crush, chew, or break it. You can take Midrid with or without food, but taking it with food may help reduce stomach upset. For adults, the recommended dose is 2 tablets at the start of a headache, followed by 1 tablet every hour as needed, but do not exceed 5 tablets in 12 hours. This medicine is not recommended for children under 12 years. Take Midrid as soon as you feel a migraine or headache beginning. It works best when used early in the attack, before the pain becomes severe. Midrid may cause dizziness or drowsiness; avoid activities requiring alertness until you know how it affects you. Frequent or excessive use of Midrid can cause rebound headaches, making headaches more frequent or severe. Do not drink alcohol when using this medicine. Combining alcohol with acetaminophen can cause severe liver damage and increase the risk of drowsiness or dizziness from Isometheptene. Store this drug at room temperature, away from moisture, heat, and light. Keep out of the reach of children.