Mezera is used for the treatment of ulcerative colitis. This is a condition where your colon (bowel) and rectum become inflamed and develop sores or ulcers. Mezera works by interfering with the certain chemicals that cause inflammation such as prostaglandins. This helps reduce the inflammation (swelling and pain) in the rectum and lower part of large bowel. Use Mezera exactly as prescribed by your doctor. Treatment is usually continued for 6 weeks. If possible, go to toilet and empty your bowels before using Mezera. The usual dose is 2 spray actuations (1 g/spray) once daily at bedtime. If you have difficulty retaining this amount of foam, it may also be used in two separate doses: one at bedtime and the other during the night or early in the morning (after excreting the first dose).
Mezera is manufactured by Avir Pharma Inc. comes from Canada. The active ingredient in Mezera is 5-aminosalicylic acid (5-ASA or mesalamine). Mezera is available as a foam enema with dosage of 1 g/actuation. The foam is provided with 14 single-use applicators. Each canister contains enough foam for 14 spray actuations. The applicators can be used to track your treatment (number of dose used/remaining).
Stop taking Mezera and call your doctor at once if you have one of these serious side effects:
• Allergic reactions
• Inflammation of heart muscle and lining around the heart
• Inflammation of pancreas
• Kidney problems
• Unusual bruising
Less serious side effects include abdominal pain, an abnormal sense of touch, diarrhea, constipation, or flatulence, disturbed vision, burning, pain or discomfort around the anus, bloating, dizziness, headache, hair loss, muscle or joint pain, lowered sperm count, numbness in hands and feet, decreased platelet count in the blood and increased sensitivity of your skin to sun and ultraviolet light. Please call your doctor if you have any further concerns or questions.
Do not take Mezera if you are allergic to mesalamine, or any of the ingredients present in Mezera, have severe kidney disease, liver disease, ulcers of the stomach or small intestine, a blockage along the urinary tract, are allergic to salicylates such as aspirin, are under 2 years of age. Mezera may interact with azathioprine (an immunosuppressant), 6-mercaptopurine and Methotrexate (used for cancer and autoimmune diseases), thioguanine (used to treat leukemia, a form of cancer), warfarin (blood thinning agent), probenecid, sulfinpyrazone (used to treat gout), spironolactone (used to treat heart failure), furosemide (used to treat high blood pressure and other heart diseases), rifampicin (used to treat tuberculosis), corticosteroids (e.g. prednisone), anti-inflammatory drugs and azathioprine.
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