Lynkuet (Elinzanetant) is a prescription medication used to treat moderate to severe vasomotor symptoms (VMS), commonly known as hot flashes and night sweats, associated with menopause. It is a non-hormonal treatment option that helps reduce both the frequency and intensity of these symptoms. The active ingredient in Lynkuet is elinzanetant. It belongs to a class of medications known as neurokinin 1 (NK1) and neurokinin 3 (NK3) receptor antagonists. It works by blocking the activity of neurokinin B and substance P at specific receptors in the brain's thermoregulatory center, helping restore the temperature balance often disrupted by declining estrogen levels during menopause.
Manufacturer Information
We currently offer the brand Lynkuet, manufactured in Canada by Bayer, in 60 mg capsules. The generic Elinzanetant is currently unavailable (at this pharmacy).
Get medical help immediately if you have any of these signs or an allergic reaction while using Lynkuet. The most common side effects of Lynkuet may include the following:
• Abdominal pain;
• Diarrhea;
• Dizziness;
• Drowsiness or sleepiness (somnolence);
• Fatigue or tiredness;
• Headache;
• Muscle spasms;
• Rash
Contact your doctor right away if you have any of the severe side effects, including:
• Central Nervous System Effects: Severe vertigo (spinning sensation), feeling faint (presyncope), or difficulty staying awake during the day;
• Liver Problems: Signs such as yellowing of the skin or eyes (jaundice), dark urine, pale stools, nausea, vomiting, or persistent upper stomach pain
These are not all of Lynkuet's side effects. Always contact your doctor if you notice any unusual symptoms.
You should not take Lynkuet if you are allergic to elinzanetant or any of its ingredients. Before you start using this medication, tell your doctor about your medical history, especially if you:
• Are breastfeeding or planning to breastfeed;
• Are pregnant or planning to become pregnant;
• Have a history of seizures or epilepsy;
• Have kidney problems;
• Have liver disease or a history of elevated liver enzymes
Tell your doctor about all your medications, including prescription, OTC, herbal supplements, and vitamins. There may be drug interactions between Lynkuet and other medicines, such as ketoconazole, ritonavir, rifampin, or carbamazepine.
Tell your doctor if you are pregnant or planning to become pregnant. Lynkuet should not be used in pregnancy as it may cause miscarriage or stillbirth. If you are of childbearing age, use effective contraception to prevent pregnancy during treatment and for at least two weeks after the last dose. It is unknown if the drug passes into human breast milk. Use of Lynkuet when breastfeeding is generally not recommended.
Use this medicine exactly as your doctor prescribes it. Lynkuet comes as a capsule that should be taken orally. Swallow the capsules whole with water. Do not cut, crush, or chew them. You can take Lynkuet with or without food. However, avoid grapefruit and grapefruit juice as they can increase the risk of side effects. Avoid driving or operating machinery until you know how the medication affects you, especially if you experience daytime drowsiness.
Store Lynkuet at room temperature between 20°C and 25°C (68°F and 77°F). Keep capsules in their original packaging until use and keep out of the reach of children.