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Kombiglyze XR (Saxagliptin/Metformin XR)

Drug:Kombiglyze XR
ManufacturerBristol-Myers Squibb
Dosage:5 mg/500 mg
Drug:Kombiglyze XR
ManufacturerBristol-Myers Squibb
Dosage:5 mg/1000 mg
Medically Reviewed By: Dr. Bolanle Aina, Pharmacist on 7/24/2023 10:20:56 AM.

Kombiglyze XR (Saxagliptin/Metformin) is a prescription combination medication that is used to control high blood sugar in people with type 2 diabetes. This medication is combined with a proper diet and exercise program. Proper control of diabetes helps to prevent kidney damage, blindness, nerve problems, loss of limbs and sexual function problems. It may also lessen your risk of a heart attack or stroke. Saxagliptin belong to a class of medications called DPP-4 inhibitors and Metformin belongs to the class of medications called biguanides. Saxagliptin works by increasing the levels of incretins, which help control blood sugar by increasing the release of insulin after a meal and decreasing the amount of sugar made by the liver. Metformin works by lowering blood sugar by helping to restore your body’s proper response to the insulin and decreasing the amount of sugar made by your liver and absorbed by your stomach or intestines. Kombiglyze XR is usually taken once a day with the evening meal.

Manufacturer Information

Canadian Pharmacy King offers the brand Kombiglyze XR from Canada and India manufactured by Bristol-Myers Squibb. There is no generic available for this medication. Kombiglyze XR is available in the strength of 2.5 mg/500, 2.5 mg/850 mg, 2.5 mg/1000 mg, 5 mg/500 mg and 5 mg/1000 mg tablets.

The common side effects of Kombiglyze XR may include diarrhea, headache, metallic taste in the mouth, nausea, upset stomach and vomiting.

Inform your doctor right away if you have any of the serious side effects such as:

• Joint pain;
• Signs of heart failure;
• Swelling of ankles or feet;
• Unusual skin blisters;
• Unusual or sudden weight gain;
• Unusual tiredness

You may get low blood sugar if this medication is prescribed with other diabetes medications. Symptoms of low blood sugar may include:

• Blurred vision;
• Dizziness;
• Fast heartbeat;
• Hunger;
• Shaking;
• Sudden sweating;
• Tingling hands or feet

This is not a complete list of side effects and others may occur. Please call your doctor if you have any further concerns or questions.

You should not take Kombiglyze XR if you are allergic to Saxagliptin or Metformin XR or if you have any other allergies. Before you start taking this medication, talk to your doctor about your medical history and about all the medications you take including OTC and herbal medications. You may experience blurred vision, drowsiness or dizziness due to extremely low or high blood sugar. You should not drive, use machinery or do any activity that requires you to be alert. Limit alcohol while taking this medication. Metformin can cause changes in the menstrual cycle and increase the chance of pregnancy. Talk to your doctor about using reliable birth control while taking this medication. This medication should not be used during pregnancy unless it is clearly needed. Metformin passes into breast milk in small amounts. It is unknown if Saxagliptin passes into breast milk.

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