Jakavi (Ruxolitinib) is a prescription medication that is used to treat people with an enlarged spleen and other symptoms of myelofibrosis, a rare type of blood cancer. Ruxolitinib belongs to the class of medications known as JAK inhibitors. It works by blocking the body from producing substances called growth factors. Growth factors cause the cells to grow and divide, and causes the blood cell and spleen problems found in these disorders. This medication does not cure these disorders but may help with some of the symptoms including abdominal discomfort, pain under left ribs, early feeling of fullness from meals, night sweats, itching and bone or muscle pain.
We currently have the brand name Jakavi from Canada manufactured by Novartis. There is no generic available for this medication. Jakavi is available in the strength of 5 mg, 10 mg, 15 mg and 20 mg tablets.
The common side effects may include dizziness, gas, headache and weight gain.
Talk to your doctor if you have any of the serious side effects such as:
• Easy bleeding/bruising;
• Unusual skin changes;
• Unusual tiredness
You should not take Jakavi if you are allergic to Ruxolitinib or if you have any other allergies. Before you start taking this medication, talk to your doctor about your medical history and about all the medications you take including OTC and herbal medications. This medication may make you more likely to get infections or worsen your current infections. Avoid contact with people who have infections that may spread. Do not have immunization or vaccinations without talking to your doctor. This medication should only be used during pregnancy if it is clearly needed. It is unknown if this medication passes into breast milk.