Frontline (Fipronil) is an over the counter medication used to kill adult fleas and ticks on dogs and cats, as well as to treat and control infestations of chewing lice. Frontline also aids in the control of sarcoptic mange infestations in dogs, and has been used to treat Cheyletiellosis (walking dandruff mite) in dogs and cats. Frontline belongs to a class of medications called phenylpyrazole antiparasitic agents, and works by interfering with the brain and spinal cord of parasites, resulting in death of the parasites. Frontline is a topical solution that collects in the oils of the skin and in the hair follicles. It is not absorbed into the body and does not circulate through the bloodstream. Through the process of translocation, it is spread over the body in about 24 hours. This medication is only for use in animals. This medication is not for use in humans. The dose of Frontline in dogs is based on the weight of the dog, and pipettes are available in 0.67 ml (for dogs up to 22 pounds), 1.34 ml (for dogs 23 to 44 pounds), 2.68 ml (for dogs 45 to 88 pounds), and 4 ml (for dogs 89 to 132 pounds). One pipette is applied topically every 30 days. For cats, pipettes are available in 0.5 ml, and one pipette is applied monthly. The topical spray is dosed for dogs and cats at 1.5 to 3 ml per pound of body weight. This correlates to 1 to 2 pumps per pound with the 250 ml bottle, and 3 to 6 pumps per pound with the 100 ml bottle. The spray is applied once monthly. Animals with long hair may need a higher dose. Follow all directions from your veterinarian. Use for the entire prescribed length of time, even if your pet feels better.
We currently offer the brand Frontline Spot On for cats and dogs, Frontline Plus for cats and dogs, and Frontline spray bottle from India. The generic version is not available.
Common side effects of Frontline may include minor irritation at the application site. As well, areas of the fur may appear oily or wet for up to 24 hours.
This is not a complete list of side effects, and others may occur. If you notice any other side effects not listed here, please contact your veterinarian. If you notice any signs of an allergic reaction in your pet, bathe your pet with mild soap and water, and seek emergency veterinary care if the signs continue.
This medication should not be used in animals with a known hypersensitivity or allergy to fipronil. Frontline Top Spot is not recommended for use in debilitated or geriatric animals. Frontline Spray Treatment is not recommended for use in pregnant, debilitated, geriatric, or nursing animals. Frontline is not recommended for use in kittens and puppies less than eight weeks of age. Frontline may interact with other medications. Consult with your veterinarian to determine if other drugs your pet is receiving could interact with Frontline. This medication should never be administered without first consulting your veterinarian. This medication is harmful to humans if swallowed, and can cause moderate eye irritation. Wash hands thoroughly with soap and water after handling, and avoid contact with eyes or clothing. If contact does occur, rinse thoroughly with water.
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