(Conjugated Estrogens/Bazedoxifene Acetate)
Duavee is a combination medication. Its primary active ingredients are bazedoxifene and conjugated estrogens. Bazedoxifene blocks estrogen from reaching certain cells in the uterus lining, which protects the uterus from overgrowth of tissue. Conjugated estrogens are a mixture of estrogens, a female sex hormone produced in the ovaries. Duavee is used to treat women after menopause in order to treat symptoms of hot flashes and prevent osteoporosis. This is a short-term treatment and should only be used with women who have NOT had a hysterectomy.
We currently stock the brand name medication, Duavee, manufactured by Pfizer and MSD (generic name: Conjugated Estrogens/Bazedoxifene Acetate). It is available in the 0.45 mg/20 mg dosage in a 28, 56, or 84 quantity prescription. Most of the medications will be dispensed out of Canada but could also be dispensed from New Zealand.
Duavee Side Effects
Contact your doctor right away if you experience any of the following serious side effects:
• Any signs of allergic reaction;
o Difficulty breathing;
o Swelling of the face, lips, tongue, or throat;
• Heart attack symptoms;
o Chest pain or pressure;
o Pain spreading to your jaw or shoulder;
• Signs of stroke;
o Sudden numbness or weakness, particularly on one side of the body;
o Sudden severe headache;
o Slurred speech;
o Problems with vision or balance;
• Signs of a blood clot;
o Sudden vision loss;
o Stabbing chest pain;
o Feeling short of breath;
o Coughing up blood;
o Pain or warmth in one of both legs;
• Swelling or rapid weight gain;
• Memory problems, confusion, or unusual behavior;
• Lump in the breast;
• Low calcium levels;
o Muscle spasms or contractions;
o Numbness or tingling around your mouth, fingers, or toes
Less serious side effects to watch for include:
• Stomach pain or discomfort;
• Throat pain;
• Neck pain
Women should not use this medication if they have undiagnosed vaginal bleeding, liver disease, any bleeding disorder, if you have major surgery, or if you’ve ever had a heart attack, stroke, blood clot, breast cancer, or cancer in the uterus/vagina. Using Duavee may increase the risk of blood clots, stroke, or heart attack. Long-term use of this medication may increase the risk of cancer in the breast, uterus, and ovaries. Use this medication at the lowest dosage needed to treat the symptoms you’re experiencing. Do not take other estrogens while on this medication.
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