Diane 35 (Ethinyl estradiol/cyproterone) is a prescription medication used to treat several types of acne in women whose antibiotics and other treatments were unsuccessful. It also treats moderate to severe acne related to androgen sensitivity or hirsutism in women of reproductive age. A high level of androgens or hypersensitivity of the sebaceous glands to a normal level of androgens causes increased sebum production and acne. The active ingredients in Diane 35 are cyproterone and ethinyl estradiol. Cyproterone belongs to a group of medications called antiandrogens. It works by blocking the effects of androgens by binding to proteins called androgen receptors. Ethinyl estradiol belongs to a group of drugs called estrogens. It works by regulating the hormones that affect the skin.
We currently offer the brand Diane 35 from Canada manufactured by Bayer and Turkey manufactured by Schering. The generic Ethinyl estradiol/cyproterone (Ginette-35) comes from India and Canada by different manufacturers.
Get medical help immediately if you have any of these signs or an allergic reaction while taking Diane 35. The most common side effects of Diane 35 may include the following:
• Abdominal cramps;
• Appetite changes;
• Breast tenderness;
• Hair loss;
• Menstrual pain;
• Weight gain
Contact your doctor right away if you have any of the serious side effects, including:
• Abnormal, uncontrollable movements in arms or legs;
• Breast lumps for women with a history of breast disease;
• Hearing changes;
• Increased blood pressure;
• Raynaud’s syndrome;
• Shortness of breath;
• Signs of depression;
• Signs of pancreatitis;
• Sudden partial or complete vision loss
These are not all of the side effects of Ethinyl estradiol/cyproterone. Always contact your doctor if you notice any unusual symptoms.
You should not take Diane 35 if you are allergic to Ethinyl estradiol, cyproterone, or any ingredient in Diane 35. Before you start taking this medication, tell your doctor about your medical history, especially if you:
• Are breastfeeding or plan to breastfeed;
• Are going to have an operation;
• Are pregnant or plan to become pregnant;
• Have a blood clotting disorder;
• Have a history of cholestatic jaundice;
• Have a history of liver tumours;
• Have active liver disease;
• Have severe diabetes with blood vessel changes;
• Have undiagnosed abnormal vaginal bleeding
You should inform your doctor if you are pregnant or planning to become pregnant. Diane 35 may harm an unborn baby. Use effective non-hormonal birth control to prevent pregnancy while taking this drug. Wait for at least one menstrual cycle after stopping treatment before trying to get pregnant. Inform your doctor if you are breastfeeding or plan to breastfeed. This drug passes into breast milk and can reduce the amount and quality of milk produced. Diane 35 may cause changes to the shape of your eyes. Contact your doctor if your contact lenses do not fit well. Keep your tablets out of sight and reach of children. Tell your doctor about all your medications, including prescription, OTC, herbal supplements, and vitamins. There may be drug interactions between Diane 35 and other medicines, including ampicillin, bosentan, clozapine, metformin, grapefruit juice, melatonin, and tetracycline. Tell Do not store above 250C.
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