Daliresp (Roflumilast) is a prescription medication used to reduce the risk of flare-ups in adults with severe Chronic Obstructive Pulmonary Disease (COPD). COPD is a progressive lung disease that makes it difficult to breathe, often caused by long-term exposure to irritating gases or particulate matter, most often from cigarette smoke. Daliresp helps to prevent the worsening of COPD symptoms but is not a bronchodilator and should not be used to treat sudden breathing problems. The active ingredient in Daliresp is Roflumilast. Roflumilast belongs to a class of medications known as phosphodiesterase-4 (PDE4) inhibitors. It works by blocking the action of the enzyme PDE4, which is involved in inflammation in the lungs and airways. By inhibiting this enzyme, Daliresp helps to decrease inflammation, which in turn reduces the frequency of COPD exacerbations.
Manufacturer Information
We currently offer the brand Daliresp from Canada and the United Kingdom, manufactured by AstraZeneca, in the strength of 500 mcg tablets. The generic Roflumilast is also available from India by a different manufacturer in the strength of 500 mcg tablets.
Get medical help immediately if you have any of these signs or an allergic reaction while using Daliresp. The most common side effects of Daliresp may include the following:
• Back pain;
• Diarrhea;
• Dizziness;
• Headache;
• Nausea;
• Weight loss
Contact your doctor right away if you have any of the severe side effects, including:
• Mental health problems;
• Significant weight loss;
• Signs of an allergic reaction, such as trouble breathing, hives, swelling of the face, lips, or throat
These are not all of the side effects of Daliresp. Always contact your doctor if you notice any unusual symptoms.
You should not use Daliresp if you are allergic to Roflumilast or any of the ingredients in Daliresp. Before you start using this medication, tell your doctor about your medical history, especially if you:
• Are breastfeeding or planning to breastfeed;
• Are pregnant or planning to become pregnant;
• Have a history of depression;
• Have liver problems;
• Have moderate or severe liver impairment;
• Have severe immunological diseases;
• Have suicidal thoughts or behavior
Tell your doctor about all your medications, including prescription, OTC, herbal supplements, and vitamins. There may be drug interactions between Daliresp and other medicines, such as phenobarbital, rifampin, carbamazepine, theophylline, cimetidine, etc. Tell your doctor if you are pregnant or planning to become pregnant. It is unknown if Roflumilast will harm an unborn baby. Discuss the potential benefits and risks associated with using this medicine during pregnancy. Inform your doctor if you are breastfeeding or planning to breastfeed. It is unknown if Roflumilast is excreted in breast milk or if it can harm a nursing infant. This medicine should be used when breastfeeding only if the potential benefits outweigh the risks.
Use this medicine exactly as your doctor prescribes it. Daliresp is a tablet. Swallow the tablet whole with a glass of water. Do not crush, chew, or break the tablet. You can take the medicine with or without food. Daliresp is a long-term maintenance treatment and will not provide immediate relief for a sudden COPD flare-up. You should have a separate rescue inhaler for that purpose. This medicine may affect your mental health. Be alert to any changes in your mood or behavior and report any new or worsening symptoms to your doctor immediately. Store Daliresp at room temperature, away from moisture and heat. Keep out of the reach of children.