Compazine (Prochlorperazine) is used to treat severe nausea and vomiting from certain causes such as surgery, or cancer. This medication belongs to a class of drugs known as phenothiazines. This medication works by blocking the action of a chemical called dopamine in the brain. This stops nausea messages from being sent to a part of your brain called the "vomiting centre".

Manufacturer Information

We currently have the brand Compazine from New Zealand (Buccastem) by Alliance Pharmaceuticals and the United Kingdom (Stemetil) manufactured by Sanofi. The generic Prochlorperazine comes from Canada by a different manufacturer.

Seek emergency medical help if you have any signs of an allergic reaction to this medication. The common side effects of Compazine may include blurred vision, dry mouth, feeling sleepy or drowsy, headaches, and stuffy nose.

Contact your doctor immediately if you have any of these serious side effects:
• Agitation, restlessness;
• Extreme drowsiness or light-headed feeling;
• Jaundice;
• Little or no urination;
• Low blood cell counts;
• Lupus-like symptoms;
• Severe constipation, bloating, stomach pain;
• Severe nervous system reaction;
• Stiffness or muscle spasms in your neck;
• Tremors or any unusual muscle movements;
• Trouble speaking or swallowing;
• Uncontrolled muscle movements in your arms, legs or face

This is not a complete list of side effects and others may occur. Please call your doctor if you have any further concerns or questions.

You should not use Compazine if you are allergic to Prochlorperazine or other phenothiazines. Do not use Compazine if you have recently used large amounts of alcohol or medication that makes you sleepy. Prior to taking this medication, tell your doctor if you have ever had:
• Breast cancer;
• Chemotherapy;
• Glaucoma;
• Heart disease;
• Low blood pressure;
• Low while blood cell counts;
• Pheochromocytoma;
• Seizures or a brain tumor

Drinking alcohol with this medication can cause side effects. Compazine may cause blurred vision, or make you dizzy or may impair your reactions. Avoid driving or hazardous activity until you know how this medication will affect you. This medication could make you sunburn more easily. Avoid sunlight or tanning beds, wear protective clothing and use sunscreen of SPF 30 or higher when you are outdoors. Tell your doctor about all the medications you take including prescription, nonprescription, herbal products, and vitamins. There may be a drug interaction between Compazine and other medications. Consult your doctor if you are pregnant or breastfeeding. Compazine is not recommended for use in children younger than 2 years.

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