Combivir is used in the treatment of the Human Immunodeficiency Virus (HIV) infection. HIV infection damages the immune system and can lead to Acquired Immune Deficiency Syndrome (AIDS) and other illnesses. Combivir belongs to a group of antiretroviral medicines called nucleoside analogue reverse transcriptase inhibitors (NRTIs), and is used in combination with other antiretrovirals to treat Human Immunodeficiency Virus (HIV) infection. Combivir does not cure AIDS or kill the HIV virus, but helps to prevent further damage to the immune system by slowing down the production of new viruses. Combivir also increases the CD4 cell count in your blood which are a type of white blood cells that are important in helping your body fight infection. Combivir tablet can be taken with or without food. If you have kidney or liver problems and your dose needs to be reduced your doctor may have you take lamivudine and zidovudine as separate medicines. Take your medicine as your doctor has told you. If you are not sure, ask your doctor or pharmacist.
Canadian Pharmacy King currently offers the the brand Combivir from Turkey manufactured by GSK and the generic Zidovudine/Lamivudine from Canada by a different manufacturer. Generic Combivir is available in the strength of 300 mg/150 mg tablets.
The common side effects of Combivir may include headache, nausea, vomiting, diarrhea, stomach pains, feeling dizzy, tiredness, lack of energy, fever, general feeling of being unwell, muscle and joint pain, skin rash, hair loss, a low red blood cell count (anaemia) or low white blood cell count, an increase in the level of liver enzymes, increased levels of lactic acid in the blood. Contact your doctor right away if you have any of the following symptoms:
• serious allergic reaction;
• symptoms of sudden wheeziness and chest pain or tightening;
• swelling of eyelids, face or lips, skin rash or ‘hives’ anywhere on the body
This is not a complete list of side effects and others may occur. Please call your doctor if you have any further concerns or questions.
Some people, especially women and those who have liver disease taking Combivir develop a condition called lactic acidosis (deep, rapid, difficult breathing, drowsiness, numbness or weakness in the limbs, nausea, vomiting, stomach pain) together with an enlarged liver. If you have any of the symptoms listed above, see your doctor as soon as possible. You should not take Combivir if you: have a very low red blood cell count (anemia) or very low white blood cell count (neutropenia), previously had an allergic reaction to Combivir or to any of the ingredients in the product. Before taking Combivir, inform your doctor if you: are pregnant or breast feeding, are taking ribavirin as it could cause or worsen anemia, are taking interferon, have any drug allergies, had, or you have, any diseases of the kidney, had, or you have, any diseases of the liver, particularly hepatitis B or C infection, had, or you have, very low red blood cell count (severe anemia), very low white blood cell count (neutropenia) or any type of blood disorder.
Tell your doctor, nurse, or pharmacist about all the medicines you take, including drugs prescribed by other doctors, vitamins, minerals, natural supplements, or alternative medicines. Combivir may interact with: acetylsalicylic acid, indomethacin, ketoprofen, naproxen, atovaquone, pyrimethamine, codeine, morphine, methadone, cimetidine, probenecid, clofibrate, vincristine, vinblastine, doxorubicin, clarithromycin to be taken 2 hours before or 2 hours after taking Combivir, interferon, Isoprinosine, ganciclovir, fluconazole, amphotericin, flucytosine, phenytoin, valproic acid, oxazepam, lorazepam, rifampicin, co-trimoxazole (trimethoprim and sulfamethoxazole), dapsone, pentamidine, sorbitol-containing medicines (usually liquids) used regularly.
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