Astagraf XL (Tacrolimus Extended Release) is used with other medications to prevent rejection of a kidney transplant. This medication belongs to a class of drugs known as immunosuppressants. It works by weakening your body’s defense system to help your body accept the new organ as if it were your own.
We currently offer the brand Astagraf XL from Canada also called Advagraf by Astellas Pharma. The generic version is not available.
Seek emergency medical help if you have any signs of an allergic reaction to this medication. The common side effects of Astagraf XL may include diarrhea, headaches, nausea or vomiting, shaking, trouble sleeping, and upset stomach.
Contact your doctor immediately if any of these serious side effects occur:
• Black or bloody stools;
• Dark urine;
• Easy bruising/bleeding;
• Hearing problems;
• Mental/mood changes;
• Muscle weakness;
• Numbness/tingling of hands and feet;
• Persistent nausea/vomiting;
• Severe leg pain;
• Severe stomach pain;
• Signs of kidney problems;
• Signs of too much acid in the blood;
• Symptoms of heart failure;
• Throwing up blood;
• Yellowing eyes/skin
This is not a complete list of side effects and others may occur. Please call your doctor if you have any further concerns or questions.
Before taking Astagraf XL, tell your doctor if you have any allergies, or are allergic to other macrolide medications. Avoid drinking alcohol while taking this medication. Prior to taking this medication, tell your doctor about your medical history and if you have any recent or current infections, or if you have ever had:
• High blood pressure;
• Kidney disease;
• Liver disease;
• Mineral imbalances
This medication may increase your risk of developing skin cancer. Limit your time in the sun. Avoid tanning booths and sunlamps. Use sunscreen and wear protective clothing when outdoors. Older adults may be more sensitive to the effects of this drug. Avoid grapefruit and grapefruit juice while taking this medication. Tell your doctor about all the medications you take including prescription, nonprescription, herbal products, and vitamins. There may be a drug interaction between Astagraf XL and other medications. Astagraf XL may increase your potassium levels; consult your doctor before using potassium supplements or salt substitutes that contain potassium. This medication can be absorbed through the skin and lungs and may harm an unborn baby. Women who are pregnant or may become pregnant should not handle this medication or breathe dust from the tablets. Consult your doctor if you are pregnant or breastfeeding.
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