Zelboraf (Vemurafenib) is a prescription medication used to treat adults with unresectable or metastatic melanoma (a type of skin cancer) that has a specific genetic mutation, known as BRAF V600. Melanoma is a serious type of skin cancer that begins in the cells (melanocytes) that produce the skin pigment melanin. Unresectable melanoma cannot be entirely removed by surgery, while metastatic melanoma has spread to other parts of the body. Approximately half of all melanomas have a BRAF gene mutation, which drives the uncontrolled cell growth. The active ingredient in Zelboraf is Vemurafenib. Vemurafenib belongs to a class of medications known as BRAF inhibitors. It works by targeting and blocking the activity of the mutated BRAF protein. By inhibiting this abnormal protein, Zelboraf helps to slow down the growth and spread of the cancer.
Manufacturer Information
We currently offer the brand Zelboraf from Canada, manufactured by Hoffman-La Roche, in the strength of 240 mg tablets. The generic Vemurafenib is currently unavailable (at this pharmacy).
CanadianPharmacyKing.com supplies only genuine Zelboraf from Canada shipped using Canadian packaging. This Zelboraf is manufactured by Genetech Inc. (a member of Roche Group), the worldwide manufacturer of Zelboraf. This offer is neither endorsed nor authorized by Genetech Inc. (the United States and Canadian distributor of Zelboraf). CanadianPharmacyKing.com has no affiliation whatsoever with Genetech Inc.
Get medical help immediately if you have any of these signs or an allergic reaction while using Zelboraf. The most common side effects of Zelboraf may include the following:
• Diarrhea;
• Fatigue;
• Hair loss;
• Headache;
• Increased sensitivity to the sun;
• Itching;
• Joint pain;
• Nausea;
• Rash
Contact your doctor right away if you have any of the severe side effects, including:
• Eye problems;
• Liver problems;
• QT prolongation;
• Signs of an allergic reaction, such as trouble breathing, hives, swelling of the face, lips, or throat
These are not all the side effects of Zelboraf. Always contact your doctor if you notice any unusual symptoms.
You should not use Zelboraf if you are allergic to Vemurafenib or any ingredient in Zelboraf. Before you start using this medication, tell your doctor about your medical history, especially if you:
• Are breastfeeding or planning to breastfeed;
• Are pregnant or planning to become pregnant;
• Have a history of liver or kidney problems;
• Have a history of long QT syndrome;
• Have a history of other skin cancers;
• Have an electrolyte imbalance;
• Have heart problems
Tell your doctor about all your medications, including prescription, OTC, herbal supplements, and vitamins. There may be drug interactions between Zelboraf and other medicines, such as atorvastatin, clarithromycin, duloxetine, pirfenidone, isoniazid, and bosutinib. Tell your doctor if you are pregnant or planning to become pregnant. Vemurafenib can harm an unborn baby. Use effective birth control to prevent pregnancy while using this medicine and for at least 2 weeks after your last dose. Inform your doctor if you are breastfeeding or planning to breastfeed. It is unknown if Vemurafenib is excreted in breast milk or if it may harm a nursing infant. Do not breastfeed while using this medicine and for at least 2 weeks after your last dose.
Use this medicine exactly as your doctor prescribes it. Zelboraf is a tablet. Swallow the tablet whole with a glass of water. Do not crush, chew, or break it. Take this medicine regularly at approximately 12 hours apart. If you vomit shortly after taking Zelboraf, do not take another dose. Wait until your next scheduled dose time to retake the medicine. You will need to undergo frequent blood tests to monitor your liver and kidney function while using this medicine. Your doctor will also regularly check your skin condition, heart function, and eye condition. Vemurafenib can increase your sensitivity to sunburn. Avoid exposure to sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors. Vemurafenib and its metabolites are excreted in body fluids, including urine, feces, vomit, and others. Because of this, caregivers must take special precautions when handling any items that may be contaminated. When cleaning up body fluids, handling soiled laundry or trash, or changing diapers, caregivers should wear disposable rubber gloves to avoid direct contact. Hands should be thoroughly washed both before putting on gloves and after removing them. Contaminated clothing, linens, or materials should be washed separately from other laundry to prevent accidental exposure. These precautions help reduce the risk of exposure to the medication. Store this drug at room temperature, away from moisture, heat, and light. Keep out of the reach of children.