Xospata (Gilteritinib) is a prescription medication used to treat adults with acute myeloid leukemia (AML). AML is a cancer of certain white blood cells. Patients with this type of cancer develop large numbers of abnormal white blood cells. This drug is used if AML is linked to an alteration of a gene called FLT3. Xospata is given after other cancer treatments did not work or have stopped working. The active ingredient in Xospata is Gilteritinib. Gilteritinib belongs to a class of drugs called kinase inhibitors. It works by blocking the action of certain enzymes needed for the abnormal cells to multiply and grow, preventing cancer growth.
Manufacturer Information
We currently offer the brand Xospata from Canada manufactured by Astellas Pharma in the strength of 40 mg tablets. The generic Gilteritinib is not available.
Get medical help immediately if you have any of these signs or an allergic reaction while using Xospata. The most common side effects of Xospata may include the following:
• Diarrhea;
• Dizziness;
• Headache;
• Nausea;
• Tiredness
Contact your doctor right away if you have any of the severe side effects, including:
• Breathing difficulties;
• Fast or pounding heartbeats;
• Flu symptoms such as mouth and throat ulcers;
• Rapid weight gain;
• Swelling in your arms, legs, underarms, groin, or neck
These are not all of the side effects of Xospata. Always contact your doctor if you notice any unusual symptoms.
You should not use Xospata if you are allergic to Gilteritinib or any ingredient in Xospata. Before you start using this medication, tell your doctor about your medical history, especially if you:
• Are breastfeeding or planning to breastfeed;
• Are pregnant or planning to be pregnant;
• Have an electrolyte imbalance;
• Have heart problems;
• Have long QT syndrome
Tell your doctor about all your medications, including prescription, OTC, herbal supplements, and vitamins. There may be drug interactions between Xospata and other medicines, like rifampicin, phenytoin, voriconazole, erythromycin, digoxin, St. John’s wort, etc. Tell your doctor if you are pregnant or planning to become pregnant. Xospata may harm your unborn baby and should not be used in pregnancy. Women taking this medication and are able to get pregnant should use an effective method of contraception during treatment and for at least 6 months after stopping treatment. If you use a hormonal contraceptive, you must also use a barrier method such as a condom or diaphragm. Men taking Xospata whose partners are able to become pregnant should use an effective form of contraception during treatment and for at least 4 months after stopping treatment. Inform your doctor if you are breastfeeding or planning to breastfeed. It is not known if Gilteritinib passes into breast milk or if it may affect a nursing infant. Do not breastfeed while using this medicine and for at least 2 months after your last dose. Use this medicine exactly as your doctor prescribes. Xospata is a tablet. Swallow the tablets whole with water, and do not crush or chew. Take the drug by mouth with or without food. Take the drug once a day at the same time each day to help you remember. Continue taking the drug for as long as your doctor tells you to. Store this medicine in its original container at room temperature, away from moisture and light. Keep out of the sight and reach of children.