Pyrazinamide belongs to the family of medicines called anti-infectives. It is used, along with other medicines, to treat tuberculosis (TB).
To help clear up your tuberculosis (TB) infection completely, you must keep taking this medicine for the full time of treatment, even if you begin to feel better. This is very important. It is also important that you do not miss any doses.
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
Pain in large and small joints
Loss of appetite; pain and swelling of joints, especially big toe, ankle, and knee; tense, hot skin over affected joints; unusual tiredness or weakness; yellow eyes or skin
Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome:
Itching; skin rash
Dosing—The dose of pyrazinamide will be different for different patients. Follow your doctor's orders or the directions on the label . The following information includes only the average doses of pyrazinamide. If your dose is different, do not change it unless your doctor tells you to do so.
For oral dosage form (tablets):
For tuberculosis (TB):
Adults and children—Dose is based on body weight. The usual dose is 15 to 30 milligrams (mg) of pyrazinamide per kilogram (kg) (6.8 to 13.6 mg per pound) of body weight once a day; or 50 to 70 mg per kg (22.7 to 31.8 mg per pound) two times a week or three times a week, depending on the schedule your doctor chooses for you. This medicine must be taken along with other medicines used to treat TB.
Missed dose—If you do miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
The generic alternative is not manufactured by the company that makes the brand product.
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