Rifater (Isoniazid/Rifampin/Pyrazinamide) contains three different medicines called isoniazid, rifampicin and pyrazinamide. They all belong to a group of medicines called anti-tuberculous drugs. They work by killing the bacteria that cause tuberculosis. Rifater Tablets are used to treat tuberculosis. Rifater Tablets make all your body ¬fluids an orange or red colour; this is normal and not harmful. While you are taking Rifater tablets, you should not eat matured cheeses, cured meat, some fish or drink wine and beer. If you get a temperature or begin to feel more unwell, lose your appetite or have yellowing of the skin or eyes, you must talk to your doctor straight away. You must take the tablets every day for the whole time the doctor has told you to take them. Do not stop and start taking the tablets. This may increase the risk of side effects and your TB will not be treated properly. Take this medicine by mouth. Swallow the tablets whole, with a drink of water. Take Rifater Tablets on an empty stomach. Take at least 30 minutes before a meal or 2 hours after a meal. Do not give this medicine to children. Your doctor may ask you to take Vitamin B6 during treatment with Rifater Tablets, especially if you are malnourished, elderly or a diabetic.
Canadian Pharmacy King currently offers the brand Rifater from UK manufactured by Sanofi Aventis the strength of 50 mg/120 mg/300 mg tablets. There is no generic available for this medication.
The common side effects of Rifater may include clumsiness or unsteadiness, coughing or spitting up blood, dark urine, fast, irregular, or racing heartbeat or pulse, loss of appetite, nausea, numbness, tingling, burning, or pain in the hands and feet, pain in the large and small joints, tightness in the chest, unusual tiredness or weakness, vomiting, yellow eyes or skin. Contact your doctor right away if you have the following symptoms:
• An allergic reaction or serious skin rashes;
• Bruise more easily than normal;
• Have blood in your urine or an increase or decrease in amount of urine;
• Flu-like symptoms including chills, fever, headache, dizziness and bone pains;
• Mental problems with unusual thoughts and strange visions (hallucinations);
• Severe watery diarrhea that will not stop and you are feeling weak and have a fever;
• Severe bleeding;
• Sudden severe headache;
• Your stomach ulcer gets worse;
• Your fits get worse or you start to have fits
This is not a complete list of side effects and others may occur. Please call your doctor if you have any further concerns or questions.
Do not take Rifater Tablets if you: are allergic to isoniazid, rifampicin, pyrazinamide, have yellowing of the skin and eyes, are taking saquinavir or ritonavir for an HIV infection. Talk to your doctor or pharmacist before taking Rifater Tablets if you: cannot tolerate some sugars, are pregnant or breast feeding, have liver problems, have kidney problems, have diabetes, you have or had gout, are coughing up blood, have epilepsy, have or had mental health problems (such as depression or schizophrenia), feel numb or weak in your arms and legs, have an HIV infection, are under weight or malnourished, drink alcohol every day, inject yourself with drugs, have a problem with bleeding or a tendency to bruise easily, wear contact lenses or if the person taking this medicine is a child or aged 65 years or older.
Please tell your doctor if you are taking any other medicines, especially medicines for: heart and blood, mental health, epilepsy, infections and the immune system, hormone and cancer, pain, gout, diabetes, relaxing muscles before surgery, erection problems such as tadalafil, medicines such as ondansetron and aprepitant, probenecid, antibiotic medicines, quinine used for malaria, theophylline used for diffculty in breathing. In particular, do not take this medicine, and tell your doctor, if you are taking: Saquinavir or ritonavir used for HIV infection. Do not drive or use any tools or machines if you feel dizzy or have problems with vision or have other side effects that could affect your ability to drive while taking this medicine.
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