Inspiolto is a combination of two medications Olodaterol and Tiotropium, that are used to make breathing easier for people who experience breathing problems due to a lung disease called Chronic Obstructive Pulmonary Disease (including chronic bronchitis and emphysema). Tiotropium is a long-acting muscarinic agent (LAMA) and olodaterol is a long-acting beta2-agonist (LABA). Olodaterol and Tiotropium relax the muscle in the walls of the small airways in the lungs. Both the medications work together to help open the airways and make it easier for the air to get in and out of the lungs. Inspiolto help prevents shortness of breath and wheezing. Always use Inspiolto exactly as prescribed by your doctor. The recommended dose of Inspiolto is 2 puffs (5 mcg tiotropium and 5 mcg olodaterol), once daily at the same time of the day, every day. Do not stop using Inspiolto or other medicines to control or treat your COPD unless told to do so by your healthcare provider because your symptoms might get worse. Your healthcare provider will change your medicines as needed.
Inspiolto is available from Canada manufactured by Boehringer Ingelheim (Canada) Ltd. Inspiolto is available as 4 mL inhalation solution. Each puff delivers 2.5 mcg tiotropium (as tiotropium bromide monohydrate) and 2.5 mcg olodaterol (as olodaterol hydrochloride) from the mouthpiece.
Inspiolto Side Effects
Stop taking Inspiolto and call your doctor at once if you have one of these serious side effects:
• High or low blood pressure
• Irregular heartbeats
• Blockage of intestines
• Urinary tract infections
• Myocardial ischemia
• Lower respiratory tract infections
• High blood sugar
• Low blood potassium levels
Less serious side effects include increase of the measured eye pressure, seeing halos around lights in association with red eyes, blurred vision, diarrhea, constipation, dry mouth, inflammation of the mouth, gums and tongue, difficulty in swallowing, heartburn, tiredness, general weakness, inflammation of the throat, nasal passages and sinuses, common cold, fungal infections of the oral cavity and throat, depletion of body water, back pain, swollen and painful joints, muscular pain, muscle spasms, dizziness, difficulty sleeping, cough, pain in mouth and throat, hoarseness, nosebleed, sore throat and discomfort when swallowing; inflammation/irritation of the vocal chords, pain while passing urine, inability to empty the bladder, rash, itching, nettle rash, infections or ulcerations of the skin, dryness of the skin. Please call your doctor if you have any further concerns or questions.
Do not use Inspiolto if you have asthma, experience sudden symptoms of COPD, are allergic to tiotropium bromide, ipratropium bromide or other anticholinergic drugs (containing atropine or its derivatives, are allergic to olodaterol hydrochloride or other drugs containing a beta agonist or any non-medicinal ingredients in the medicine, are less than 18 years of age. Inspiolto can lead to dizziness and blurred vision. In case you experience these symptoms, you not drive or operate heavy machinery. Inspiolto should not be used with antidepressants, in particular tricyclic antidepressants and monoamine oxidase inhibitors (MAOIs), medicines similar to Inspiolto such as ipratropium, tiotropium, glycopyrronium, aclidinium, umeclidinium used for your lung disease, medicines that decrease the level of potassium in your blood such as diuretics, other bronchodilators such as methylxanthines (e.g. theophylline) or steroids (e.g. prednisolone), beta-blockers used in the treatment of high blood pressure or other heart problems (e.g. propranolol) or in the treatment of glaucoma (e.g. timolol).
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