Enbrel is a medicine for treatment of people with moderate to severe forms of rheumatoid arthritis (RA), juvenile idiopathicarthritis (JIA), and a type of disease called psoriatic arthritis. It is also used for treating adults with a type of arthritis called ankylosing spondylitis (AS). Enbrel is also used for treatment of moderate to severe psoriasis in adults and children. Psoriasis is an inflammatory disease that affects skin and causes raised, thick, red and scaly patches that can appear anywhere on the body. Psoriatic arthritis is usually seen in patients with Psoriasis and affects both the joints and the skin. Enbrel is a type of protein called a tumour necrosis factor (TNF) blocker that blocks the action of a substance your body makes called TNF-alpha. TNF-alpha is made by your body’s immune system. People with immune diseases like RA, JIA, Psoriatic Arthritis and Psoriasis, as well as patients with AS, have too much TNF-alpha in their bodies, which can cause inflammation and lead to painful, swollen joints and raised thick, red, scaly patches (“psoriatic skin lesions”) that can appear anywhere on the body. Enbrel can reduce the amount of TNF in the body to normal levels, helping to treat joint damage and skin lesions. Enbrel may be effective in reducing signs and symptoms of inflammatory arthritis (such as pain, morning stiffness and fatigue), may help improve your ability to do simple daily activities (such as dressing, walking and climbing stairs), and may help prevent damage to your bones and joints. In patients with psoriatic skin conditions, Enbrel may be effective in clearing skin and improving quality of life (such as personal relationships, work and daily activities, and treatment satisfaction).
Enbrel is manufactured by Amgen and comes from Canada. Enbrel is available as a lyophilized powder in a multiple-use vial containing 25mg etanercept per vial. Enbrel is also available as a single-use prefilled syringe in 25mg and 50mg dosage strengths. The medication is available for LOCAL PICKUP only.
Stop taking Enbrel and call your doctor at once if you have one of these serious side effects:
• Blood problems
• Heart problems
• Liver problems
• Nervous system disorders
• Serious infections such as tuberculosis
Less serious side effects include injection site reactions such as mild and included redness, swelling, itching, or bruising. These usually go away within 3 to 5 days. If you have pain, redness or swelling around the injection site that doesn’t go away or gets worse, call your doctor. Other side effects include headaches and upper respiratory infections (sinus infections). Please call your doctor if you have any further concerns or questions.
Do not take Enbrel if you are allergic to etanercept Before taking the injection, tell your doctor if you have an infection, congestive heart failure, hepatitis B, are pregnant or breastfeeding. Enbrel may interact with methotrexate, Kineret, Orencia, cyclophosphamide.